Effects of AGN and D/DA on TRAMP dorsolateral prostate lession progression and associated cell cycle regulatory genes. A. Representative immunohistochemical analysis of SV40-T antigen (T-Ag) and Ki-67 expression in DLP. Magnification, 200×. Dark brown nuclear staining. B. Mean score of DLP lesions. 16 weeks, Vehicle (TRAMP), n=13; AGN (TRAMP) n=11; D/DA (TRAMP) n=10. 28 weeks, Vehicle (TRAMP), n=13; AGN (TRAMP) n=15; D/DA (TRAMP) n=14. C. Real time qRT-PCR analysis of mRNA levels in 28-week pooled DLP. One-way ANOVA followed by the Dunnett post test, *: P<0.05, **: P<0.01, ***: P<0.001.