Figure 7. Schematics summarizing the results of the present study.

A, Labeling of progenitors in the subpallium by IUE caused the labeling of neurons in the neocortex, hippocampus, olfactory bulb and nucleus accumbens (green arrows), but the labeling of both neurons and astrocytes in the olfactory tubercle, amygdala, striatum, globus pallidus and piriform neocortex (red arrows). Dotted green arrows represent the supply of astrocytes to a restricted region within the indicated structure. Fate-mapping using Nkx2.1^Cre; Ai9 mice caused the labeling of only neurons even in the piriform neocortex, dorsal striatum and most amygdalar regions (green arrows), indicating astrocytes in these regions originate from Nkx2.1^- PD. B, Schematics illustrating the association of neuron-astrocyte and astrocyte-astrocyte originating from distinct PDs. Essentially, the distribution of neurons and astrocytes depends on PDs, however, in certain regions such as the striatum and piriform cortex, neurons and astrocytes originating from distinct PDs are closely associated (circled region). This might be due to across-region tangential migration of neurons (dotted arrows). Although the regions of astrocyte distribution were generally segregated from those originating from distinct PDs, astrocytes from distinct domains were intermingled in certain regions such as the ventral part of the striatum and olfactory tubercle (region shown by rectangle).