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. 2015 Jul 15;5:11979. doi: 10.1038/srep11979

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Copyright © 2015, Macmillan Publishers Limited

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By real-time RT-PCR, liver mRNA levels of AFP and transcription factors were compared between control (gray bar) and liver-specific ZBTB20 KO (LZB20KO, black bar) mice at the age of 6 months, with 36B4 as internal control. AFP mRNA levels in LZB20KO liver were approximately 6,000-fold higher than control (a). The expression levels of transcriptional activators HNF1α, HNF1β, C/EBPα, C/EBPβ, HNF3α, HNF3β, and HNF3γ in LZB20KO livers did not differ significantly from control (b). HNF1β was increased, but did not reach significance. The expression levels of AFP repressors NF1, COUP-TF1, Zhx2, and p53 in LZB20KO livers did not differ significantly from control (c). Zhx2 was decreased, but did not reach significance. The expression levels of cell proliferation regulators c-Myc, c-Jun, and Jun B in LZB20KO livers did not differ significantly from control (d).