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. 2015 Jul 21;5:12373. doi: 10.1038/srep12373

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Copyright © 2015, Macmillan Publishers Limited

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Only patients with suspicion of a high grade glioma based on initial screening of the presenting MRI scans were included in the study. These patients then underwent a preoperative functional imaging study with subsequent distribution into Friedlein grading system A (functionally silent area of the brain or adjacent to functionally eloquent areas of the brain) and B (in functionally eloquent areas of the brain). Following surgery, only patients with glioblastoma underwent further analysis with classification as Friedlein grading A (amenable to gross total resection) and Friedlein grading B (amenable to biopsy or at most subtotal resection). Following this, parameters like progression-free interval, overall survival time and postoperative complications were separately investigated.