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. 2015 Nov 17;10(11):e0143223. doi: 10.1371/journal.pone.0143223

Fig 3. DNA double-strand breaks (DSBs) up-regulate Adcy1 in cumulus cells and down-regulate Pde3a in cumulus-enclosed oocytes.

Fig 3

(A) Adcy1 is up-regulated in the cumulus cells from cumulus oocyte complexes (COCs)with DNA DSBs.(B) The expression of Gpr3 and Pde3a in oocytes from normal and DNA DSB COCs. (C)The expression of Gpr3 and Pde3a in normal and DNA DSB denuded oocytes. **, highly significant difference, p < 0.01; *, significant difference, 0.01 < p < 0.05.