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. 2015 Nov 17;10(11):e0143223. doi: 10.1371/journal.pone.0143223

Fig 5. Model of cumulus cell regulating oocyte meiosis when the COC DNA was DSB.

Fig 5

The DNA DSBs (Green) increase the transcription of Adcy1 (red) and cAMP production in cumulus cells. cAMPs are transported from cumulus cells to oocytes through gap junctions. The Gpr3 maintains the cAMP level in oocytes and Pde3a hydrolyze cAMPs in oocytes. The transcription of Gpr3 showed no significant change in DSB oocytes, where Pde3a (blue) is down regulated in DSB oocytes. Enrichment of cAMP in oocytes induce the oocyte GVBD block. DSB, DNA double-strand breaks; GVBD, germinal vesicle breakdown.