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. 2015 Nov 17;11(11):e1005284. doi: 10.1371/journal.ppat.1005284

Fig 8. A proposed model.

Fig 8

Influenza virus infection induces the accumulation of pericentrosomal ERC through the activation of Rab11a GTPase and microtubule formation from the centrosome. YB-1 is required for anchoring of nucleated microtubules at the centrosome. Along with the formation of pericentrosomal ERC, cholesterol accumulates in ERC with vRNP in an YB-1-dependent manner. The recycling endosome for transport of vRNP emanates from the cholesterol-enriched ERC, and the cholesterol in the recycling endosome may be a trigger for budozone formation concomitantly with vRNP trafficking.