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. Author manuscript; available in PMC: 2015 Nov 17.
Published in final edited form as: Nature. 2015 Sep 23;526(7571):131–135. doi: 10.1038/nature15260

Figure 3. Early stage metastatic cells possess a distinct basal/stem-cell program.

Figure 3

a, PCA plots show metastatic and primary tumour cells in representative mice. Low, high and intermediate indicate burden levels. b, Bar graph shows genes from the 49-gene differentiation signature, and pluripotency genes, that were differentially expressed in low-burden metastatic cells.

*P <0.05, significant relative to primary tumour; primary tumour expression =0. P values and fold change are listed in Extended Data Table 2. Mets, metastases. c, Heatmap and dendrogram show unsupervised hierarchical clustering of metastatic cells and genes from the 49-gene signature that were run on all arrays. BM, bone marrow; BR, brain; LN, lymph node; LU, lung; PB, peripheral blood; T, tumour.