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. Author manuscript; available in PMC: 2016 Jan 30.
Published in final edited form as: Nature. 2015 Jun 22;523(7562):592–596. doi: 10.1038/nature14467

Fig. 1. Dendritic spines are dynamic in CA1 hippocampus of the adult mouse.

Fig. 1

(a) A sealed, glass guide tube implanted dorsal to CA1 allows time-lapse in vivo imaging of dendritic spines.

(b) A doublet microendoscope projects the laser scanning pattern onto the specimen plane in tissue. Inset: Red lines indicate optical ray trajectories.

(c) CA1 dendritic spines in a live Thy1-GFP mouse.

(d) Time-lapse image sequences. Arrowheads indicate spines that either persist across the sequence (white arrowheads), disappear midway (red), arise midway and then persist (green), arise midway and then later disappear (yellow), or disappear and then later appear at an indistinguishable location (cyan).