Table 2.
Individual Patient Characteristics (N=28)
| Patient | Prev Nephrectomy (prior to Gem) |
Tumor- histologic type (pathology reports) |
Tumor histo grade |
Prognostic Score |
LDH 1.5 ULN |
Hemoglobin <12g/dL |
Calcium >10.2g/dL |
Time from diagnosis to treatment <1 year |
Number of risk factors |
Karnofsky score (0– 100) |
Sites of metastasis |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Yes | clear cell type | Fuhrman grade 3 | 2 | 0 | 1 | 1 | 1 | 4 | N/D | Bone, Lungs, Liver |
| 2 | Yes | clear cell type | Fuhrman grade 4 | 1 | 0 | 1 | 0 | 0 | 1 | N/D | Lung |
| 3 | Yes | clear cell with sarcomatoid differentiation (30–40%) | Fuhrman Grade 4 | 1 | 0 | 1 | 0 | 1 | 2 | N/D | Bone, Lung, Abdomen |
| 4 | Yes | clear (90%)and eosinophillic (5–10%) type | Fuhrman Grade 4 | 1 | 0 | 0 | 0 | 1 | 1 | N/D | Lung, Pleura |
| 5 | No | poorly differentiated carcinoma | N/D | 1 | 1 | 1 | 0 | 1 | 3 | N/D | Muscle, Nodes, Adrenal |
| 6 | Yes | clear cell type with sarcomatoid differentiation (40–50%) | Fuhrman Grade 4 | 0 | 0 | 1 | 0 | 1 | 2 | N/D | Bone, Lung, Pleura |
| 7 | Yes | clear cell type | Fuhrman Grade 3 | 2 | 1 | 0 | 0 | 0 | 2 | N/D | Pericardium, Mediastinum, Chest Cavity, Pleura |
| 8 | Yes | papillary type 1 | Fuhrman Grade 2 | 1 | 0 | 1 | 0 | 1 | 2 | N/D | Nodes |
| 9 | Yes | clear cell type | Fuhrman’s Nuclear Grade 2 | 1 | 0 | 1 | 0 | 1 | 2 | N/D | Bone Brain, Nodes Adrenal |
| 10 | Yes | unclassified type | Fuhrman Grade 4 | 1 | 0 | 0 | 0 | 1 | 1 | N/D | Bone Lung, Nodes, Liver |
| 11 | No | poorly differentiated carcinoma | N/D | 0 | 0 | 1 | 0 | 1 | 2 | N/D | Nodes, Adrenal |
| 12 | No | unclassified type | N/D | 1 | 0 | 1 | 0 | 1 | 2 | N/D | Nodes |
| 13 | No | metastatic pleomorphic carcinoma with clear and granular cells | N/D | 2 | 1 | 1 | 0 | 1 | 4 | N/D | Skin, Bone |
| 14 | No | chromophobe | N/D | 3 | 1 | 0 | 1 | 3 | N/D | Nodes, Liver | |
| 15 | No | rhabdoid features | Fuhrman Grade 4 | 3 | 0 | 1 | 1 | 1 | 4 | N/D | Retroperitoneal Space, Bone, Lung, Peritoneum, Liver |
| 16 | Yes | clear cell type | Fuhrman Grade 3 | 1 | 0 | 1 | 0 | 1 | 2 | N/D | Retroperitoneal Space, Lung, Pleura, Nodes, Liver, Duodenum, Adrenal, Bone |
| 17 | Yes | clear cell type with sarcomatoid diffentiation (20%) | Fuhrman’s Nuclear Grade 4 | 1 | 1 | 1 | 0 | 1 | 3 | N/D | Nodes, Spine, Bone, Lung, |
| 18 | Yes | clear cell type | Fuhrman’s Nuclear Grade 3 | 0 | 0 | 1 | 0 | 1 | 2 | N/D | Lung |
| 19 | No | poorly differentiated renal neoplasm with focal sarcomatoid features | N/D | 3 | 0 | 0 | 0 | 1 | 2 | N/D | Nodes |
| 20 | Yes | clear cell type | Fuhrman’s Nuclear Grade 4 | 1 | 0 | 1 | 1 | 1 | 3 | N/D | Lungs, Nodes Adrenal |
| 21 | No | poorly differentiated renal cell carcinoma | N/D | 1 | 0 | 1 | 0 | 1 | 2 | N/D | Peritoneum (Generalized) |
| 22 | Yes | clear cell type with sarcomatoid differentiation (30–40%) | Fuhrman’s Nuclear Grade 4 | 3 | 1 | 0 | 1 | 3 | N/D | Lung, Liver, Adrenal, Nodes | |
| 23 | Yes | clear cell type with focal sarcomatoid features (15–20%) | Fuhrman’s Nuclear Grade 4 | 2 | 0 | 1 | 0 | 1 | 3 | N/D | Lung |
| 24 | Yes | sarcomatoid type | N/D | 3 | 0 | 1 | 0 | 1 | 3 | N/D | Bones, Lung, Pleura, Nodes |
| 25 | No | clear cell type | N/D | 3 | 1 | 1 | 0 | 1 | 4 | N/D | Bones, Lung, Nodes, Liver, Left Adrenal |
| 26 | Yes | clear cell with sarcomatoid differentiation | Fuhrman’s Nuclear Grade 4 | 1 | 0 | 1 | 0 | 1 | 2 | N/D | Lung, Renal bed |
| 27 | Yes | clear cell with sarcomatoid differentiation | N/D | 1 | 0 | 1 | 0 | 0 | 1 | N/D | Lung, lymph nodes |
| 28 | Yes | clear cell with sarcomatoid differentiation | N/D | 1 | 0 | 1 | 0 | 1 | 2 | N/D | Lung, brain |