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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Ultrasound Med Biol. 2015 Aug 28;41(11):2938–2954. doi: 10.1016/j.ultrasmedbio.2015.07.016

Table 3.

Histotripsy Treatment Results: Ultrasound Heated Samples.

HIFU Heating Histotripsy Lesion (# Samples/Total Samples)
Tissue
Type 		Peak
Temp 		Heating
Duration 		No Visible
Damage 		Surface Damage
Only 		Partial Damage
(No Perforation) 		Complete Damage
(Perforation)
Tongue Control 0 0/6 0/6 6/6 0/6
~60°C 10 minutes 0/6 0/6 0/6 6/6
~90°C 10 minutes 0/6 6/6 0/6 0/6
 
Liver Control 0 0/6 0/6 6/6 0/6
~60°C 10 minutes 0/6 0/6 0/6 6/6
~90°C 10 minutes 0/6 0/6 6/6 0/6
 
Tendon Control 0 6/6 0/6 0/6 0/6
~60°C 30 minutes 0/6 6/6 0/6 0/6
~90°C 30 minutes 0/6 0/6 6/6 0/6

Histotripsy treatment results demonstrated an increase in susceptibility to histotripsy-induced tissue damage for tongue, liver, and tendon heated with ultrasound at a peak temperature of ~60°C. Tongue and liver samples heated with ultrasound at a peak temperature of ~90°C were less susceptible to histotripsy while tendon became more susceptible to histotripsy after heating at ~90°C.