Fig. 1.
Schematic representation of the A2BAR cDNA and protein sequence in SS-Adora2b mutant rats. SS-Adora2b mutant rats contain a 162-bp in-frame deletion that results in the removal of the start codon. Assuming translation proceeds utilizing the next potential start codon located at position 650, SS-Adora2b mutant rats are predicted to express a truncated form of the A2BAR consisting of transmembrane segments 5–7 and the C terminus. a Schematic illustration of cDNA sequence (deleted segment = gray; region predicted to be untranslated = dark gray). b 3-D illustration of the A2BAR protein predicted to be expressed in the mutant rat line (expressed regions = blue/green; unexpressed regions = gray)