Fig. 1.

The extracellular catabolism of ATP is slower in mucosal-denuded detrusor strips from patients with outflow obstruction due to benign prostatic hyperplasia (BPH) as compared to control organ donors (Control). ATP (30 μM) was added at zero time to the incubation medium. Samples were collected from the incubation fluid at the indicated times on the abscissa and analyzed by HPLC with UV detection to quantify ATP (filled circles) and its metabolites, ADP (open lozenges), and AMP (filled triangles). Average results obtained from six control individuals (a, c) and five BPH patients (b, d); the vertical bars represent SD and are shown when they exceed the symbols in size