Table 5.

Analysis of variance of the Box-Behnken design response

Source of variation	Sum of squares	df	Mean square	Ratio	P-value (significance)
Regression	1791.9	14	127.995	242.0044	<0.01*
	68.9242	44	1.56646
Lack of fit	53.5862	15	3.57241	6.7544	<0.01*
Error	15.3380	29	52.8898
Total	1860.86	58

*Significant at the 99 % level