Table 3.

Treatment-related adverse events

Adverse event		Dose-level					Total
		1	2	3	7	5
	No. of patients	3	4	8	10	8	33
Fatigue	All grades	2 (67)	3 (75)	7 (88)	7 (70)	5 (63)	24 (73)
	Grade ≥3	0	0	1 (13)	0	0	1 (3)
Nausea	All grades	1 (33)	4 (100)	7 (88)	4 (40)	7 (88)	23 (70)
	Grade ≥3	0	0	1 (13)	0	0	1 (3)
Diarrhea	All grades	2 (67)	2 (50)	4 (50)	5 (50)	6 (75)	19 (58)
	Grade ≥3	0	0	1 (13)	1 (10)	1 (13)	3 (9)
Elevated ALAT	All grades	1 (33)	3 (75)	5 (63)	5 (50)	4 (50)	18 (55)
	Grade ≥3	0	1 (25)	2 (25)	1 (10)	2 (25)	6 (18)
Elevated ASAT	All grades	1 (33)	3 (75)	5 (63)	4 (40)	4 (50)	17 (52)
	Grade ≥3	0	1 (25)	3 (38)		1 (13)	5 (15)
Rash*	All grades	0	2 (50)	4 (50)	5 (50)	4 (50)	15 (46)
	Grade ≥3	0	0	0	0	0	0
Neutropenia	All grades	2 (67)	2 (50)	1 (13)	5 (50)	3 (38)	13 (39)
	Grade ≥3	2 (67)	2 (50)	1 (13)	5 (50)	3 (38)	13 (39)
Vomiting	All grades	0	2 (50)	5 (63)	2 (20)	2 (25)	11 (33)
	Grade ≥3	0	0	1 (13)	0	0	1 (3)
Fever	All grades	1 (33)	1 (25)	2 (25)	2 (20)	2 (25)	8 (24)
	Grade ≥3	0	0	0	0	0	0
Mucositis#	All grades	0	1 (25)	1 (13)	2 (20)	3 (38)	7 (21)
	Grade ≥3	0	0	0	0	0	0

Treatment-related adverse events per dose-level. *includes desquamation, acneiform, erythema. # both clinical examination and symptomatic