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. 2015 Nov 18;35(46):15276–15290. doi: 10.1523/JNEUROSCI.1834-15.2015

Figure 7.

Figure 7.

Loss of PGC-1α enhances gamma oscillations and impairs nest building. A, Example traces of oscillations recorded in stratum pyramidale in CA3 in slices from PGC-1α+/+ (top) and PGC-1α−/− (bottom) mice after application of 100 nm kainate. Scale bars, 100 ms, 0.02 mV. B, Group results for the power as a function of frequency (n = 19 slices, 4 mice PGC-1α+/+; n = 18 slices, 4 mice PGC-1α−/−). C, The average power in the gamma range (20–80 Hz) is enhanced in PGC-1α−/− mice. D, The peak power is enhanced in PGC-1α−/− mice. E, However, the peak frequency is not altered between the two genotypes. F, Example images of nests built by PGC-1α+/+ and PGC-1α−/− mice after 18 h. The nest generated by the PGC-1α+/+ mouse scored a 5, whereas the nest built by the PGC-1α−/− mouse scored a 3. G, PGC-1α−/− mice build nests with lower scores compared with PGC-1α+/+ mice (n = 13, 10). *p < 0.05, Student's t test.