Table 5.
A summary of HRs for the overall and subgroup analyses of SALP and OS of osteosarcoma patients.
| Number of studies | Patients number | HR (95% CI) | Heterogeneity | |||
|---|---|---|---|---|---|---|
| Chi-squared | I 2 | p value | ||||
| Overall | 17 | 2272 | 1.82 (1.61–2.06) | 13.68 | 0% | 0.622 |
| Age | ||||||
| Preadult and adult | 14 | 2088 | 1.82 (1.60–2.06) | 10.83 | 0% | 0.625 |
| Preadult only | 3 | 184 | 1.87 (1.20–2.91) | 2.84 | 2.96% | 0.242 |
| Enneking stage | ||||||
| II | 7 | 910 | 1.75 (1.42–2.15) | 3.53 | 0% | 0.740 |
| II-III | 8 | 1211 | 1.77 (1.61–2.06) | 6.02 | 0% | 0.538 |
| III | 2 | 151 | 2.67 (1.75–4.06) | 0.71 | 0% | 0.400 |
| Sample size | ||||||
| <100 | 11 | 751 | 2.13 (1.70–2.66) | 10.94 | 8.6% | 0.362 |
| >100 | 6 | 1521 | 1.71 (1.48–1.98) | 0.20 | 0% | 0.999 |
| Geographic region | ||||||
| Asia | 6 | 734 | 1.89 (1.55–2.31) | 4.16 | 0% | 0.527 |
| Non-Asia | 11 | 1538 | 1.78 (1.53–2.07) | 9.29 | 0% | 0.505 |
HR: hazard ratio, OS: overall survival, and CI: confidence interval.