TABLE 4.

Inhibitory effect of alkyl phospholipid miltefosine on planktonic cells, biofilm formation, and preformed biofilms of Candida albicans transcription factor mutant library

Target	Gene	IC90 for planktonic cells (μg/ml)	BMIC (μg/ml)
			Biofilm formation		Preformed biofilm
			BMIC50	BMIC90	BMIC50	BMIC90
Drug response	TAC1	1	2	4	8–16	32
	RME1	2	1–2	4	8	32
	CRZ1	2	1–2	2	2	8
	MRR1	1–2	2	4	2–4	8
	NDT80	1	1–2	2	32–64	64
	FCR1	1–2	2	4	8–16	32
	CAP1	1	2	4	8	16
Stress response	WAR1	1	0.5	2	8	32
	MNL1	2	2	2	8–16	32
	NRG1	1–2	NDb	ND	ND	16
Cell wall	RLM1	2	1–2	2	2–4	8
	CAS5	2	2	4	2–4	8
	SKO1	1	1–2	2–4	8	32
Cell respiration/metabolism	HAP5	1	1–2	2	32–64	64
	HAP3	1	1	4	8–16	32
Ergosterol	UPC2	2	2–4	4–8	2–4	8
Adherence, biofilm, and virulence	EFG1	0.5–1	1–2	2	4–8	8–16
	ACE2a	1	4	8–16	2–4	4–8
	BCR1a	2	2–8	8	16–32	32
C. albicans SN152	Parental strain	1–2	2	4	8	16–32

^aNot a good biofilm-forming strain.

^bND, not defined.