TABLE 1.
Analysis of the thyA genes from revertant strains in comparison to genes of their parent isolates
| Parent strain and variant | TD phenotypea | Alteration(s) in thyAb | Predicted alteration or point mutation (position)c | Reference or source |
|---|---|---|---|---|
| Normal-5 | − | G564T | Trp → Tyr (188) | 1 |
| SCV-5 | + | T564G | Trp → stop (188) | 1 |
| Revertant-5 | − | T562C, T564G | Trp → Gln (188) | This study |
| Normal-6 | − | 1 | ||
| SCV-6 | + | C941A | Ala → Asp (314) | 1 |
| Revertant-6 | − | C941T | Ala → Phe (314) | This study |
| Normal-7 | − | 24 | ||
| SCV-7 | + | C705A | Ser → Arg (235) | 24 |
| Revertant-7 | − | This study | ||
| Newman WT | − | 24 | ||
| Newman SCV | + | G748T | Glu → stop (249) | 24 |
| Newman revertant | − | G748A | Glu → Lys (249) | This study |
a
TD, thymidine-dependent.
b
Only nonsynonymous mutations in thyA compared to the thyA gene of S. aureus 8325-4 are shown.
c
Amino acid position.