FIG 2.
In vivo dose-dependent effects of dalbavancin against seven select S. aureus isolates in a neutropenic mouse thigh model. (A) Dalbavancin exposure expressed at dose level (mg/kg/12 h). (B) Exposure expressed as fAUC/MIC. Each symbol represents the mean and standard deviation from four thighs. Dalbavancin exposure is expressed as the 24-h fAUC/MIC. The burden of organisms was measured at the start and end of therapy. The horizontal dashed line at 0 represents the burden of organisms in the thighs of mice at the start of therapy. Data points below the line represent killing, and points above the line represent growth. R2 represents the coefficient of determination. The 50% effective dose (ED50) represents the AUC/MIC associated with 50% of the maximal effect (Emax), and N is the slope of the relationship or the Hill coefficient. The line drawn through the data points is the best-fit line based on the sigmoidal Emax formula.