TABLE 1.
Key P. aeruginosa isolates studied in resistance selection and animal efficacy experimentsa
| Isolate | Acquired β-lactamaseb | Amp regulonc | Iron relatedd |
|---|---|---|---|
| ARC545 (PAO1) | None | No predicted LOF alteration | No predicted LOF alteration |
| ARC3483 (PAO1 ΔampC ΔpoxB) | None | No predicted LOF alteration | No predicted LOF alteration |
| ARC3502 | VIM-1 | No predicted LOF alteration | No predicted LOF alteration |
| ARC3506 | VEB-1, OXA-10 | No predicted LOF alteration | No predicted LOF alteration |
| ARC3514 | KPC-2 | No predicted LOF alteration | No predicted LOF alteration |
| ARC4659 | None | No predicted LOF alteration | No predicted LOF alteration |
| AZ 8-18 | None | No predicted LOF alteration | No predicted LOF alteration |
| AZ 32-13 | None | No predicted LOF alteration | No predicted LOF alteration |
| JJ 4-36 | None | No predicted LOF alteration | No predicted LOF alteration |
| JJ 5-35 | None | No predicted LOF alteration | No predicted LOF alteration |
| JJ 8-16 | None | E163* in AmpD | No predicted LOF alteration |
| JJ 11-54 | None | No predicted LOF alteration | No predicted LOF alteration |
a
See Table S5 in the supplemental material for a detailed description of the genotypes. LOF, loss of function.
b
All isolates contained chromosomal ampC and poxB genes.
c
Amp regulon includes ampD, ampR, and dacB.
d
Siderophore-related genes were piuA, piuC, pirA, pirR, fecI, pvdA, pvdS, and fpvA.