TABLE 2.
In vitro activity of SMC-3176 against clinical isolates of P. aeruginosa (n = 20) containing various β-lactamases
| Isolate | Acquired β-lactamasea | MIC in MHB (mg/liter) |
|||
|---|---|---|---|---|---|
| SMC-3176 | Aztreonam | Ceftazidime | Meropenem | ||
| ATCC 27853 | None | 0.5 | 4 | 2 | 1 |
| ARC3502 | VIM-1 | 0.12 | 64 | >64 | >64 |
| ARC3504 | SHV-2 | 0.06 | 64 | 32 | 4 |
| ARC3505 | PER-1, OXA-10 | 0.5 | >64 | >64 | 4 |
| ARC3506 | VEB-1, OXA-10 | 0.12 | >64 | >64 | 8 |
| ARC3509 | None | 0.06 | >64 | >64 | 16 |
| ARC3511 | KPC-2 | 0.06 | >64 | 64 | 32 |
| ARC3514 | KPC-2 | 0.06 | >64 | >64 | >64 |
| ARC3606 | TEM-24 | 0.06 | 16 | 64 | 4 |
| ARC3607 | OXA-2 | 4 | 64 | >64 | 8 |
| ARC3611 | None | 0.5 | 32 | 32 | 4 |
| ARC3612 | None | 0.06 | 16 | 64 | 16 |
| ARC3727 | VIM-2, OXA-4 | 0.25 | 16 | 32 | >64 |
| ARC3729 | VEB-1, OXA-10 | 0.25 | >64 | >64 | 16 |
| ARC3756 | IMP-18, VIM-2, OXA-2 | 0.25 | 16 | >64 | >64 |
| ARC3916 | GES-1, OXA-2 | 0.12 | 16 | >64 | 16 |
| ARC3925 | VIM-2 | 0.12 | 32 | 32 | >64 |
| ARC4060 | PER-1, OXA-10 | 0.06 | >64 | >64 | 16 |
| ARC4063 | VEB-1 | 0.5 | >64 | >64 | 32 |
| ARC4068 | IMP-15, OXA-2 | 0.016 | 32 | >64 | >64 |
a
All isolates contained chromosomal ampC and poxB genes.