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Susceptibility of isogenic P. aeruginosa isolates containing knockout mutations in genes related to siderophore receptors
| Mutation | MIC in MHB (mg/liter) |
|||||
|---|---|---|---|---|---|---|
| SMC-3176 | MB-1 | MC-8 | Aztreonam | Ceftazidime | Meropenem | |
| (PAO1, parent) | 0.25 | 0.5 | 0.5 | 4 | 2 | 1 |
| ΔpiuA | 4 | 16 | 8 | 16 | 4 | 2 |
| ΔpiuC | 16 | 32 | 8 | 16 | 4 | 1 |
| ΔpirA | 0.5 | 0.5 | 1 | 16 | 4 | 2 |
| ΔpiuA + ΔpirA | 32 | 64 | >64 | 8 | 4 | 2 |
| ΔtonB1a | >64 | >64 | >64 | 8 | 2 | 2 |
MIC determined in medium supplemented with 160 μM Fe(SO4).
