TABLE 5.
fT>MIC associated with various efficacy endpoints for SMC-3176 against P. aeruginosa in the neutropenic mouse thigh model
| Isolate | MIC (mg/liter) in: |
% fT>MIC (% CV) by CDMHB MIC ata: |
||||
|---|---|---|---|---|---|---|
| MHB | CDMHB | Stasis | 1-log kill | 2-log kill | EI80 | |
| PAO1 | 0.25 | 0.12 | 68.0 (1.1) | 71.3 (1.3) | 76.6 (2.0) | 76.5 (2.3) |
| ARC3502 | 0.12 | 0.25 | 72.9 (1.2) | 76.5 (1.1) | 81.1 (1.2) | 84.1 (2.3) |
| ARC3506 | 0.12 | 0.25 | 63.4 (1.2) | 66.9 (1.2) | 71.3 (1.9) | 74.3 (3.1) |
| ARC4659 | 8 | 0.5 | 59.4 (1.2) | 63.5 (1.5) | 71.4 (2.5) | 70.3 (3.3) |
| JJ 4-36 | 0.12 | 0.06 | Indeterminable | Indeterminable | Indeterminable | Indeterminable |
a
Indeterminable indicates that exposures for efficacy could not be appropriately determined against isolate JJ 4-36, due to the lack of a well-corresponding PK/PD relationship.