Isobolograms of in vitro sensitivities of asexual stages of three P. falciparum strains as well as the 3D7α-tubII/GFP stage IV gametocytes to the PQ-X drug combination at fixed drug concentration ratios. Fractional inhibitory concentrations (FICs) of PQ against various X (CQ,black; MQ, red; PPQ, green; NQN, yellow; LMF, blue) in asexual cultures of strains HB3 (A), 3D7 (B), and Dd2 (C) and gametocytes of 3D7α-tubII/GFP (D). Error bars indicate standard errors of the mean.