TABLE 1.
In vitro sensitivities of asexual stage parasites (strains HB3, 3D7, and Dd2) and 3D7α-tubII/GFP stage IV gametocyte to six antimalarials
| Drug | Mean (SEM) IC50 ofa: |
|||
|---|---|---|---|---|
| HB3 (nM) | 3D7 (nM) | Dd2 (nM) | 3D7α-tubII/GFP (μM) | |
| CQb | 15.7 (± 4.8) | 29.7 (± 6.0) | 154.4 (± 13.2) | 30.7 (± 4.0) |
| MQ | 12.9 (± 4.9) | 11.8 (± 1.9) | 22.1 (± 3.1) | 23.6 (± 3.5) |
| NQN | 13.6 (± 7.1) | 9.8 (± 4.8) | 19.8 (± 0.4) | 6.18 (± 1.1) |
| PPQ | 15.2 (± 3.5) | 18.6 (± 2.9) | 24.2 (± 1.4) | 271.8 (± 86.9) |
| LMF | 60.5 (± 18.6) | 29.5 (± 14.7) | 63.9 (± 0.79) | 559.0 (± 8.6) |
| PQ | 1,930.1 (± 440.0) | 1,016.5 (± 254.2) | 2,551.4 (± 948.0) | 18.9 (± 2.0) |
a
The IC50s of asexual stage parasites were measured using the SYBR green I assay, while the IC50s of gametocytes were determined using the flow cytometry-based method.
b
Significant differences in IC50s between CQS and CQR parasites (ANOVA, P < 0.05).