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In vitro selection of penicillin resistance. Graphs show changes in subinhibitory concentrations for mutant mecC-MRSA strains LGA251ΔblaZ and 02.5099.DΔblaZ (A) or wild-type mecC-MRSA strains LGA251 and 02.5099.D (B), during the course of in vitro penicillin resistance selection (A) or penicillin and clavulanic acid selection (B), grown in continuous culture with Iso-Sensitest broth at 37°C. Arrows indicate time points selected for mecC gene sequencing.
