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. 2015 Nov 17;59(12):7308–7315. doi: 10.1128/AAC.01944-15

FIG 3.

FIG 3

Biofilm formation on implanted coupons in BALB/cJ female mice. (A) Biofilm on implanted coupons. Data were pooled from 2 independent experiments (with an NRS234 inoculation dose of 2.8 × 108 and 1.7 × 108 CFU per mouse, respectively). A total of 10 mice are represented in each group. Means are represented by horizontal lines. *, P < 0.05. (B) Rate of implanted coupon retention of infected mice. Data were pooled from 3 independent experiments (with an NRS234 inoculation dose of 1.2 × 109, 1.2 × 109, and 2.0 × 109 CFU per mouse, respectively). A total of 15 mice were represented in the uncoated group, and 14 mice were in the coated group. (C) Skin lesion size of infected mice as described for panel B. (D) L-929 mouse fibroblast cell viability (as determined by mitochondrial reduction of MTT substrate) when cultured with TMS/O2 1:4 coupons normalized to the value of cells cultured with uncoated controls, which was defined as 100%. The data are presented as means ± standard errors of the means for a total of 9 samples (pooled from 3 independent experiments in triplicates).