TABLE 2.
Mutation frequency results and susceptibility results for plates containing fosfomycin concentrations at 5 times the MIC for the three challenge isolates
| Escherichia coli isolate | Avg mutation frequencya |
MICb (mg/liter) |
||
|---|---|---|---|---|
| 5× MIC | 256× MIC | With 25 mg/liter g-6-P | Without 25 mg/liter g-6-P | |
| ATCC 25922 | 3.5 × 105 | >1.2 × 109 | 32–64 | 32–64 |
| 13319 | 4.5 × 106 | >8.9 × 108 | 32–64 | 32–64 |
| 2692 | 8.1 × 105 | >1.6 × 109 | 32–64 | 32–64 |
a
The average mutation frequency was calculated to be 1 CFU of resistant bacteria in the indicated number of CFU/ml.
b
MICs of isolates from plates containing drug concentrations at 5 times the MIC were determined using the agar susceptibility methodology. g-6-P, glucose-6-phosphate.