FIG 1.

Fungal burdens in brain (A) and spinal cord (B) from mice with CNS coccidioidomycosis treated with VT-1161 or fluconazole for 7 days and sacrificed 2 days later. Horizontal bars represent mean values. All treatments significantly reduced brain and spinal cord CFU counts compared to treatment with placebo (P < 0.001). Activity of VT50 was superior to that of VT25 in both brain (P = 0.036) and spinal cord (P = 0.036) and also to that of fluconazole (P < 0.001, both comparisons). Activity of VT25 was superior to that of fluconazole in brain (P = 0.007) but not in spinal cord (P = 0.136). VT25, VT-1161 25 mg/kg; VT50, VT-1161 50 mg/kg (*, 10/11 mice had no fungal growth from spinal cord at time of sacrifice).