FIG 3.

Brain fungal burdens of mice from the CNS coccidioidomycosis survival study. Mice were treated for 14 days, after which they were observed for 28 days. Fungal burden was quantitated when mice required sacrifice during the study or at the study termination. CFU counts for individual mice are shown in a scatterplot, with horizontal bars representing mean values. VT-1161 significantly reduced fungal burdens compared to placebo (P = 0.001) and fluconazole (P < 0.001) treatment. No statistically significant difference was observed between placebo and fluconazole results (P = 0.197). VT25, VT-1161 25 mg/kg per day. Fluconazole was given at 25 mg/kg twice daily.