TABLE 1.
Parameter | Value for the indicated drug (μg/ml)a |
|||||
---|---|---|---|---|---|---|
C. immitis (n = 23) |
C. posadasii (n = 29) |
Coccidioides spp. (n = 52) |
||||
VT-1161 | Fluconazole | VT-1161 | Fluconazole | VT-1161 | Fluconazole | |
MIC range | 1–4 | 4–16 | 1–4 | 4–16 | 1–4 | 4–16 |
MIC50 | 2 | 8 | 1 | 8 | 1 | 8 |
MIC90 | 2 | 16 | 2 | 16 | 2 | 16 |
GMb MIC | 1.48 | 8.50 | 1.43 | 8.19 | 1.45 | 8.33 |
C. immitis strains were isolated from patients in central California, while C. posadasii strains were isolated from patients in Arizona (n = 10), California (n = 1), Texas (n = 14), and other miscellaneous locations (n = 4).
Geometric mean.