FIG 5.
Antibacterial activity of Ga-PPIX against experimental infections. Monolayers of A549 human alveolar epithelial cells (A and B) and G. mellonella larvae (C and D) were infected with A. baumannii ATCC 19606T strain (A and C) or ACICU strain (B and D) in the absence or the presence of either 20 μg/ml or 40 μg/ml of Ga-PPIX. Data shown in panels A and B represent the means (± SEM) of experiments performed twice in octuplet (n = 16) using fresh biological samples each time. Responses to the presence of Ga-PPIX were compared to those detected with bacteria cultured in the absence of this metalloporphyrin derivative. Values that are significantly different from the value for the control (0 μg/ml Ga-PPIX) are indicated by asterisks as follows: *, P = 0.037; **, P = 0.014; ***, P = 0.0005.