TABLE 2.
MICs of B. cenocepacia strains for β-lactam antibiotics with and without the inhibitor clavulanate
| Strain | MIC (μg/ml)a |
|||||||
|---|---|---|---|---|---|---|---|---|
| AMPb | AMP-CLAc | CAZ | CAZ-CLA | CTXM | CTXM-CLA | MER | MER-CLA | |
| WTd | 4,000 | 4,000 | 2 | 1 | 20 | 15 | 4 | 4 |
| M-Dup1e | 6,000 | 6,000 | 60 | 60 | 800 | 600 | 18 | 15 |
| M-Del1 | 5,500 | 5,000 | 55 | 50 | 700 | 600 | 17 | 15 |
| M-Sub2 | 6,000 | 6,000 | 60 | 60 | 800 | 800 | 15 | 15 |
| M-Sub4 | 6,000 | 6,000 | 60 | 60 | 800 | 700 | 15 | 15 |
| M-Sub5 | 6,000 | 6,000 | 60 | 60 | 750 | 700 | 18 | 18 |
| M-Sub8 | 7,000 | 6,000 | 70 | 60 | 800 | 800 | 18 | 18 |
| M-Sub14 | 7,000 | 6,000 | 65 | 60 | 800 | 700 | 18 | 18 |
a
MICs were determined by the agar dilution method.
b
Abbreviations for the antibiotics and the inhibitor (CLA) used: AMP, ampicillin; CLA, clavulanate; CAZ, ceftazidime; CTXM, cefotaxime; MER, meropenem.
c
CLA was used at a concentration of 1 μg/ml.
d
Wild-type strain.
e
ampD mutations in the strain.