TABLE 3.
Association of genotype and drug sensitivity values
| Drug | IC50 (nM) |
|||||||
|---|---|---|---|---|---|---|---|---|
|
Pfmdr-1 |
Pfcrt |
|||||||
| N86 | 86Y | Y184 | 184F | D1246 | 1246Y | CVNMK | CVIET | |
| CQ | 19.55 | 91.21a | 18.75 | 24.03 | 19.72 | 44.66 | 16.18 | 76.43a |
| MQ | 31.29 | 14.04 | 20.45 | 43.17a | 32.43 | 17.53 | 32.27 | 19.18 |
| AQ | 11.96 | 22.34 | 11.44 | 14.11 | 12.11 | 13.65 | 11.99 | 15.08 |
| ARS | 1.59 | 1.61 | 1.58 | 2.00 | 1.59 | 1.22 | 1.51 | 1.24 |
| DHA | 7.67 | 9.72 | 7.55 | 7.49 | 8.14 | 5.63 | 8.27 | 5.53 |
a
A significant difference in the IC50 was observed for comparisons between parasites harboring the wild-type genotype and those harboring mutant genotypes.