TABLE 3.
RPV susceptibilities of HIV-1 and RT-SHIV with select mutations identified in plasma and tissue vRNA
| Virus | Mutation(s) in RT sequence | EC50 (nM)a | Fold change from WT virusb |
|---|---|---|---|
| HIV-1 | WT | 0.67 ± 0.08 | 1.0 |
| E138G | 0.94 ± 0.03 | 1.4 | |
| E138Q | 2.85 ± 0.08 | 4.3 | |
| A33V | 0.42 ± 0.07 | 0.6 | |
| Y181H | 0.17 ± 0.02 | 0.3 | |
| A33V, Y181H | 0.13 ± 0.01 | 0.2 | |
| RT-SHIV | WT | 0.35 ± 0.06 | 1.0 |
| E138G | 0.76 ± 0.12 | 2.2 | |
| E138Q | 0.30 ± 0.05 | 0.8 |
a
Values are means and standard deviations from 3 independent experiments, each performed in triplicate.
b
Fold change is calculated as the ratio of the mean EC50 of mutant to WT virus.