Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Molecular representation of the acyl-enzyme complex of CMY-2 (A) and CMY-33 (B) as Connolly surface, with FEP docked in the active site. The model suggests that the reason for increased drug hydrolysis is the ready formation of Michaelis complex (kcat is greater, Km is lower). In particular, two different possible conformations were seen in the widened active site of CMY-33, suggesting the structural basis for resistance in CMY-33 versus CMY-2.
