Table 2.
Fold Change in mRNA Expression of Genes Encoding TLR Signaling Pathways Following JEV Infection in Neuro2a Cells, Suckling and Adult Mouse Brains as Compared with Respective Controls
| Symbol | Description | Fold regulation of genes in JEV infected N2a 18hrs PI | Fold regulation of genes in JEV infected suckling mice | Fold regulation of genes in JEV infected adult mice |
|---|---|---|---|---|
| Btk | Bruton agammaglobulinemia tyrosine kinase | 40.2244 | 21.7458 | 7.5597 |
| Casp8 | Caspase 8 | 5.0982 | 20.2896 | 3.7278 |
| Ccl2 | Chemokine (C-C motif ) ligand 2 | 25.1067 | 1.2888 | 434.9348 |
| Cd14 | CD14 antigen | 661.6846 | 2.2028 | 10.471 |
| Cd80 | CD80 antigen | 115.7606 | 13.2937 | 5.7292 |
| Cd86 | CD86 antigen | 30.91 | 5.049 | 62.178 |
| Cebpb | CCAAT/enhancer binding protein (C/EBP), beta | 2.1735 | −1.2289 | 7.1025 |
| Chuk | Conserved helix-loop-helix ubiquitous kinase | 3.2603 | 2.2387 | −2.4823 |
| Clec4e | C-type lectin domain family 4, member e | 5.4453 | 13.7943 | 7.3022 |
| Csf2 | Colony stimulating factor 2 (granulocyte-macrophage) | 49.8665 | 71.4733 | 3.9132 |
| Csf3 | Colony stimulating factor 3 (granulocyte) | 59.7141 | 38.8363 | 2.6543 |
| Cxcl10 | Chemokine (C-X-C motif ) ligand 10 | 40.2244 | −1.0238 | 1604.973 |
| Elk1 | ELK1, member of ETS oncogene family | 64.8934 | 10.8478 | 1.374 |
| Fadd | Fas (TNFRSF6)-associated via death domain | 58.892 | 35.0012 | −7.37 |
| Fos | FBJ osteosarcoma oncogene | 3.7581 | −1.4546 | 11.0681 |
| Hmgb1 | High mobility group box 1 | −1.0425 | 1.3973 | −6.0279 |
| Hras1 | Harvey rat sarcoma virus oncogene 1 | 4.7899 | 2.0223 | −2.2842 |
| Agfg1 | ArfGAP with FG repeats 1 | 3.3987 | 2.0505 | −1.3582 |
| Hspa1a | Heat shock protein 1A | 33.2435 | 2.2284 | 60.4778 |
| Hspd1 | Heat shock protein 1 (chaperonin) | −2.2038 | −1.2204 | −1.8682 |
| Ifnb1 | Interferon beta 1, fibroblast | 87.4266 | 10.0526 | 106.7933 |
| Ifng | Interferon gamma | 59.7141 | 26.7723 | 122.644 |
| Ikbkb | Inhibitor of kappaB kinase beta | 4.9588 | 4.8433 | 4.464 |
| Il10 | Interleukin 10 | 6.2767 | 19.0625 | 275.9634 |
| Il12a | Interleukin 12A | 18.3156 | 28.2334 | 12.8023 |
| Il1a | Interleukin 1 alpha | 28.1488 | 6.9451 | 60.06 |
| Il1b | Interleukin 1 beta | 24.3357 | 3.0652 | 9.2428 |
| Il1r1 | Interleukin 1 receptor, type I | 13.6895 | 4.8545 | 1.6799 |
| Il2 | Interleukin 2 | 82.1393 | 321.6468 | 3.9132 |
| Il6 | Interleukin 6 | 5.7557 | 3.4967 | 529.4437 |
| Il6ra | Interleukin 6 receptor, alpha | 83.575 | 4.7767 | 11.1451 |
| Irak1 | Interleukin-1 receptor-associated kinase 1 | 3.6808 | 2.2439 | −2.7543 |
| Irak2 | Interleukin-1 receptor-associated kinase 2 | 12.5099 | 8.1267 | −1.8425 |
| Irf1 | Interferon regulatory factor 1 | 5.7757 | 1.9534 | 105.2979 |
| Irf3 | Interferon regulatory factor 3 | 30.437 | 8.1643 | 1.049 |
| Jun | Jun oncogene | 5.1515 | 1.325 | 17.4885 |
| Lta | Lymphotoxin A | 59.7141 | 55.9474 | −4.6968 |
| Muc13 | Mucin 13, epithelial transmembrane | 358.294 | 43.4917 | 48.4469 |
| Ly86 | Lymphocyte antigen 86 | 30.91 | 1.6125 | 6.7194 |
| Ly96 | Lymphocyte antigen 96 | 8.7241 | 5.4114 | 3.6259 |
| Map2k3 | Mitogen-activated protein kinase kinase 3 | 4 | 4.3149 | −1.5819 |
| Map2k4 | Mitogen-activated protein kinase kinase 4 | 2.5937 | 2.5245 | −3.014 |
| Map3k1 | Mitogen-activated protein kinase kinase kinase 1 | 21.0391 | 4.6353 | 2.8056 |
| Map3k7 | Mitogen-activated protein kinase kinase kinase 7 | 3.0525 | 2.323 | −2.5344 |
| Mapk8 | Mitogen-activated protein kinase 8 | 12.2101 | 1.8566 | 1.1316 |
| Mapk8ip3 | Mitogen-activated protein kinase 8 interacting protein 3 | 2.7321 | 1.5721 | −5.2114 |
| Mapk9 | Mitogen-activated protein kinase 9 | 4.724 | 3.1009 | −4.4743 |
| Myd88 | Myeloid differentiation primary response gene 88 | −1.87 | −1.239 | 4.0655 |
| Nfkb1 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 | 5.0281 | 2.9133 | 3.8861 |
| Nfkb2 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 59.5075 | 8.1832 | 8.6239 |
| Nfkbia | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 5.0806 | 1.4136 | 5.8496 |
| Nfkbib | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | 59.7141 | 8.5307 | 1.4126 |
| Nfkbil1 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 | 19.9733 | 7.1075 | 10.1847 |
| Nfrkb | Nuclear factor related to kappa B binding protein | 25.0198 | 3.2852 | 4.0793 |
| Nr2c2 | Nuclear receptor subfamily 2, group C, member 2 | 12.1257 | 2.9336 | −1.6377 |
| Peli1 | Pellino 1 | 7.0861 | 1.6733 | 1.9431 |
| Pglyrp1 | Peptidoglycan recognition protein 1 | 141.5335 | 2.9745 | 1.6567 |
| Ppara | Peroxisome proliferator activated receptor alpha | 29.0406 | 23.7414 | −1.1906 |
| Eif2ak2 | Eukaryotic translation initiation factor 2-alpha kinase 2 | 7.235 | 2.484 | 8.0463 |
| Ptgs2 | Prostaglandin-endoperoxide synthase 2 | 157.0413 | 3.0866 | 310.475 |
| Rel | Reticuloendotheliosis oncogene | 12.1257 | 6.6162 | 1.7151 |
| Rela | V-rel reticuloendotheliosis viral oncogene homolog A (avian) | 5.3889 | 2.2232 | 1.7634 |
| Ripk2 | Receptor (TNFRSF)-interacting serine-threonine kinase 2 | 5.8971 | 2.6995 | 4.1077 |
| Tbk1 | TANK-binding kinase 1 | 8.1117 | 3.2625 | 4.8177 |
| Ticam1 | Toll-like receptor adaptor molecule 1 | 3.0951 | 9.754 | 9.3718 |
| Ticam2 | Toll-like receptor adaptor molecule 2 | 59.7141 | 24.7496 | 3.3831 |
| Tirap | Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein | −1.257 | 5.6542 | 1.1634 |
| Tlr1 | Toll-like receptor 1 | 1.07141 | 3.9705 | 3.8861 |
| Tlr2 | Toll-like receptor 2 | 4.6448 | 2.2647 | 146.8636 |
| Tlr3 | Toll-like receptor 3 | 14.6721 | 2.8695 | 7.353 |
| Tlr4 | Toll-like receptor 4 | 2.182 | 7.1075 | 38.5413 |
| Tlr5 | Toll-like receptor 5 | 2.07859 | 17.0221 | −1.4953 |
| Tlr6 | Toll-like receptor 6 | 8.604 | 7.6529 | 4.1077 |
| Tlr7 | Toll-like receptor 7 | 1.4964 | 6.0461 | 12.8023 |
| Tlr8 | Toll-like receptor 8 | 1.04244 | 8.7705 | 1.09925 |
| Tlr9 | Toll-like receptor 9 | 8.0084 | 3.6706 | 14.69 |
| Tnf | Tumor necrosis factor | 116.9704 | 6.9612 | 174.6513 |
| Tnfaip3 | Tumor necrosis factor, alpha-induced protein 3 | 4.9588 | 2.6135 | 26.1426 |
| Tnfrsf1a | Tumor necrosis factor receptor superfamily, member 1a | 5.7958 | 6.3614 | 2.6728 |
| Tollip | Toll interacting protein | 2.9588 | 3.6791 | −1.5494 |
| Tradd | TNFRSF1A-associated via death domain | 3.8906 | 4.0727 | 1.1394 |
| Traf6 | Tnf receptor-associated factor 6 | 10.5195 | 7.4093 | 1.5565 |
| Ube2n | Ubiquitin-conjugating enzyme E2N | 18.5713 | 2.0985 | −7.4213 |
| Ube2v1 | Ubiquitin-conjugating enzyme E2 variant 1 | 2.4033 | 1.3098 | −1.7552 |
Genes exhibiting significant upregulation (>2) are depicted in bold fonts, while those significantly downregulated (<− 2) are depicted in italics.