Figure 6.

ATAC-Seq Analysis of BMP4-Treated G26 and NS-1 Cells

(A) PCA plot shows ATAC-seq data.

(B) Heatmap generated for those loci that failed to be closed during BMP-induced differentiation in G26 compared to normal NS cells. KEGG glioma gene proximal loci (<10 kb) are labeled in red; cell-cycle genes in blue are the shared glioma cell-cycle loci in black.

(C) Genome browser view of the IGF1 glioma locus is shown.

(D) Motif enrichment analysis identified a high frequency of SOX motifs within those peaks identified in (B); two top motifs (lowest adjusted p values) for SOX2 are shown (see also Table S1 for full motif sets).