Figure 8. Biosynthesis pathway for the teichoic acid repeating unit in S. pneumoniae (black; Spr numbers represents S. pneumoniae R6 proteins) highlighting similar or homologous genes in S. oralis (red; Sor numbers represents S. oralis Uo5 proteins).

The biosynthesis pathway of TAs in S. pneumoniae R6 and identity to S. oralis Uo5 proteins is according to reference²⁴. (§) The gene encoding this protein was identified in the genome of an S. pneumoniae serotype 5 strain, which has been shown to incorporate Gal instead of Glc into its WTA²⁵. (#) Neither the genes encoding the proteins responsible for the addition of the α-Gal and acetyl residue to the β-Gal, nor the time point of these modifications in the biosynthesis pathway have been identified so far.