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. 2015 Nov 18;5:16828. doi: 10.1038/srep16828

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The superposition of CaSor (magenta) and apoSor (blue) reveals the conformational variation induced by calcium (yellow spheres). The green arrows represent the axis of the D helix in the two structures: the binding of three Ca²⁺ to each Sorcin monomer causes a large movement of the D helix that drags the EF1-EF2 region. The panels illustrate the changes of EF1, EF2 and EF3 taken alone, analysed aligning the C-terminal helix for each EF-hand: EF1 and EF3 open upon Ca²⁺-binding, while EF2 is almost unchanged.