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. 2014 Oct 9;5(10):e1452. doi: 10.1038/cddis.2014.403

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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The JNK pathway regulates a Dilp8-dependent developmental delay. (a) Effects of puc overexpression (UAS-puc) (gray) and puc mutant heterozygosity (puc^E69/+) (black) compared with control (white) in a vg-GAL4, UAS-Psn, UAS-Psn/+ (plain bars) or vg-GAL4/+ (hatched bars) background on the mean time of adult eclosion. Error bars represent the S.E.M. (n=4). Asterisks indicate significant difference (P<10⁻⁴, ANOVA). (b) Distribution of notched-wing phenotypes of vg-GAL4, UAS-Psn, UAS-Psn/+ UAS-puc/+ (gray bars) and vg-GAL4, UAS-Psn, UAS-Psn/+ puc^E69/+ (black bars) flies compared with vg-GAL4, UAS-Psn, UAS-Psn/+ flies (open bars). (c, d) Intensity of GFP reflecting dilp8 expression in vg-GAL4, UAS-Psn, UAS-Psn/+ dilp8^MI00727/+ (c left, d white bars), vg-GAL4, UAS-Psn, UAS-Psn/+ dilp8^MI00727/UAS-puc (c center, d gray bar), and vg-GAL4, UAS-Psn, UAS-Psn/+ dilp8^MI00727/puc^E69(c right, d black bar) third-instar wing imaginal discs. Error bars represent the S.E.M. of at least eight independent experiments. Asterisks indicate significant difference (P<10⁻³, ANOVA)