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. 2014 Oct 2;5(10):e1434. doi: 10.1038/cddis.2014.410

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons licence, users will need to obtain permission from the licence holder to reproduce the material. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/

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Modulation of IAP proteins and role of Apollon in the response of melanoma to the combination of target-specific inhibitors and TRAIL. (a) Modulation of IAP proteins by treatment of two melanoma cells lines (Me13 and Me41) with AZD6244 (A), BEZ235 (B) TRAIL (T) and their combinations (AB, ABT); NT: untreated. (b and c) Effect of Apollon silencing on mitochondrial depolarization (b) and cell death (c) in Me41 cells treated with the indicated agents and their combinations. (b and c) Mean values (±S.D.) for three independent experiments; statistical analysis in panels (b and c) by ANOVA followed by SNK test; ***P<0.001. **P<0.01. *P<0.05. NS, not significant