Figure 6.

Tumor growth inhibition in vivo, by AZD6244 and TRAIL treatment, is associated with promotion of melanoma apoptosis and reduction of Apollon expression. (a) Female SCID mice (n=7/group) bearing Me13 xenografts were treated between day 11 and day 25 (dotted line) with AZD6244, TRAIL or their combination. Statistical analysis by mixed models ANOVA; ****P<0.0001; **P<0.01. (b) Immunohistochemistry analysis of tumor nodules removed from control and treated mice. Insets, higher magnification of a representative area of each panel. Original magnification, × 20. NS, not significant