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. 2014 Oct 2;5(10):e1434. doi: 10.1038/cddis.2014.410

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons licence, users will need to obtain permission from the licence holder to reproduce the material. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/

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Inhibition of pro-angiogenic molecules and anti-angiogenic effects of AZD6244 plus TRAIL treatment in vivo. (a) Immunohistochemistry analysis for HIF-1α, VEGFα and IL-8 of Me13 tumor nodules removed from control and treated mice. Insets, higher magnification of a representative area of each panel. Original magnification, × 20. (b) Hematoxylin–eosin staining of neoplastic nodules from mice treated with AZD6244, TRAIL and their combination. Arrows: large blood vessels. (c) Staining of Me13 nodules for murine CD31 endothelial cell marker. Two representative fields (left and middle panel) and a higher magnification area (inset, right panel) are shown for each treatment group