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. 2014 Oct 9;5(10):e1454. doi: 10.1038/cddis.2014.413

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons licence, users will need to obtain permission from the licence holder to reproduce the material. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/

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Synergistic effects of ABT-737 on CPT-induced cytotoxicity against colorectal cancer cell lines achieved by co-encapsulation in PEG-PLGA NPs. (a) Combination indices obtained from MTT cell viability data following treatment of HCT116 cells with a range of polymer concentrations for 48 h, mean±S.E.M., n=3. (b) Caspase 3/7 activity following treatment of different colorectal cancer cell lines with ABT-737 (4 μM) or CPT (500 nM) in single- or dual-loaded NPs, mean±S.E.M., n≥3. (c) Effect of NP formulations on PARP cleavage in HCT116 cells following treatment for 24/48 h