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Chemosensitizing effect of ABT-737/CPT dual-loaded NPs against HCT116 xenografts. (a) HCT116 xenograft volume over time; the dashed lines indicate the days of treatment with NPs containing 2.1 mg/kg CPT or 50 mg/kg ABT-737, mean±S.E.M., n≥6; significance was assessed in comparison to Blank NPs or between the two treatment groups on day 28. (b) Kaplan–Meier survival analysis using 500 mm3 as the study end point. (c) Body weight over the time course, mean±S.E.M., n≥3
