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. 2014 Oct 30;5(10):e1503. doi: 10.1038/cddis.2014.452

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons licence, users will need to obtain permission from the licence holder to reproduce the material. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/

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(a) Triphenyltetrazolium chloride staining showing infarct size (white zone) in sections taken from hearts after sham surgery or at sham, 6 h and 24 h post permanent LAD ligation surgery. (b) Myocardial infarct size was expressed as a percentage of the left ventricle area (mean±S.E.M. (n=4/groups)). (c) Representative immunoblots showing the expression of apoptotic markers, cleaved casapse-8 and caspase-3 and necroptosis markers, RIP1 and RIP3 in sham hearts compared with tissues taken from hearts at 6 h and 24 h following permanent LAD ligation surgery (n=3 per group)