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. 2014 Oct 30;5(10):e1506. doi: 10.1038/cddis.2014.466

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons licence, users will need to obtain permission from the licence holder to reproduce the material. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/

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MALAT1 level is significantly upregulated in diabetic animal models. (a) Total RNAs were collected from the retinas of 1, 3, and 5 month after diabetes induction. Quantitative reverse transcriptase–PCRs (qRT-PCRs) were performed to detect MALAT1 levels in the retinas of STZ-induced diabetic rats and their respective non-diabetic controls. Relative MALAT1 expression was shown as the fold increase compared with the respective control (mean±S.E.M., n=6, *P<0.05). (b) qRT-PCRs were performed to detect the levels of MALAT1, vascular endothelial growth factor (VEGF), and PDEF in the retinas of db/db mice and their respective non-diabetic controls. Relative gene expression was shown as the fold increase compared with the respective control (mean±S.E.M., n=6, *P<0.05)