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. 2015 Nov 18;5:16672. doi: 10.1038/srep16672

Table 2. Meta-analysis of interleukin-related gene polymorphisms in Graves’ ophthalmopathy.

Gene Polymorphism No. ofcohorts Ethnicity Geneticmodel Total allele orgenotype counts
 FEM or REMa
 Heterogeneity
 Egger’stest (P)
Case Control OR (95% CI) P P (Q) I2 (%)
IL1A rs1800587 2 Chinese, Iranian T vs. C 480 1252 1.62 (1.00–2.62) 0.050 0.14 53.7 n.a.
      TT vs. TC + CC 240 626 2.39 (1.07–5.37) 0.039 0.25 23.6 n.a.
      TT + TC vs. CC 240 626 1.80 (0.86–3.78) 0.12 0.15 51.7 n.a.
      TT vs. CC 172 500 2.66 (0.41–17.22) 0.31 0.13 57.0 n.a.
      TC vs. CC 221 613 1.52 (1.04–2.22) 0.034 0.37 0.0 n.a.
IL1B rs1143634 3 Chinese, Caucasians, Iranian, T vs. C 650 736 0.93 (0.62–1.40) 0.72 0.85 0.0 0.61
      TT vs. TC + CC 325 368 1.02 (0.62–1.67) 0.94 0.73 0.0 0.75
      TT + TC vs. CC 325 368 0.37 (0.10–1.32) 0.13 0.85 0.0 0.82
      TT vs. CC 89 63 0.38 (0.10–1.40) 0.15 0.92 0.0 0.85
      TC vs. CC 247 308 0.33 (0.09–1.22) 0.10 0.72 0.0 0.84
IL1B rs16944 4 Chinese, Caucasians, Iranian C vs. T 1030 1880 1.09 (0.93–1.28) 0.29 0.69 0.0 0.89
      CC vs. CT + TT 515 940 1.11 (0.87–1.40) 0.41 0.97 0.0 0.68
      CC + CT vs. TT 515 940 1.13 (0.83–1.54) 0.45 0.15 38.9 0.95
      CC vs. TT 261 455 1.18 (0.83–1.67) 0.36 0.31 7.2 0.85
      CT vs. TT 333 650 1.10 (0.79–1.52) 0.58 0.11 46.2 0.90
IL1RA A2/non-A2b 2 Caucasians A2 vs. Non-A2 284 256 1.45 (0.89–2.35) 0.13 0.68 0.0 n.a.
IL4 rs2070874 3 Chinese, Iranian T vs. C 333 692 0.93 (0.74–1.17) 0.52 0.30 22.3 0.37
      TT vs. TC + CC 333 692 0.88 (0.66–1.18) 0.39 0.44 7.5 0.26
      TT + TC vs. CC 333 692 0.95 (0.54–1.65) 0.84 0.16 0.0 0.060
      TT vs. CC 212 457 1.16 (0.54–2.47) 0.71 0.18 41.3 0.1
      TC vs. CC 154 284 0.97 (0.55–1.72) 0.92 0.15 0.0 0.050
IL6 rs1800795 2 Caucasians, Iranian C vs. G 316 456 1.29 (0.66–2.54) 0.45 0.040 77.3 n.a.
      CC vs. CG + GG 158 228 1.48 (0.65–3.37) 0.36 0.12 58.3 n.a.
      CC + CG vs. GG 158 228 1.53 (0.41–5.78) 0.53 0.040 76.5 n.a.
      CC vs. GG 78 107 2.04 (0.36–11.64) 0.42 0.020 80.9 n.a.
      CG vs. GG 119 184 1.34 (0.43–4.20) 0.62 0.080 67.2 n.a.
IL12B rs3212227 2 Japanese, Iranian A vs. C 306 566 0.60 (0.26–1.39) 0.23 0.010 85.4 n.a.
      AA vs. AC + CC 153 283 0.46 (0.13–1.66) 0.24 0.020 82.5 n.a.
      AA + AC vs. CC 153 283 0.57 (0.20–1.59) 0.28 0.070 68.8 n.a.
      AA vs. CC 74 147 0.35 (0.06–2.04) 0.24 0.010 84.2 n.a.
      AC vs. CC 123 202 0.81 (0.49–1.32) 0.39 0.30 7.0 n.a.
IL13 rs1800925 3 Chinese, Japanese, Caucasians C vs. T 566 904 1.08 (0.82–1.41) 0.59 0.27 29.5 0.17
      CC vs. CT + TT 283 452 1.14 (0.83–1.58) 0.42 0.51 0.0 0.70
      CC + CT vs. TT 283 452 0.88 (0.45–1.73) 0.71 0.27 30.2 0.12
      CC vs. TT 200 301 0.92 (0.46–1.84) 0.82 0.26 31.5 0.11
      CT vs. TT 99 175 0.84 (0.41–1.71) 0.63 0.36 12.2 0.19
IL13 c.-2044G>A 2 Japanese, Caucasians G vs. A 382 760 1.02 (0.77–1.36) 0.87 0.31 2.3 n.a.
      GG vs. GA + AA 191 380 0.99 (0.70–1.41) 0.97 0.56 0.0 n.a.
      GG + GA vs. AA 191 380 1.14 (0.55–2.34) 0.73 0.18 45.5 n.a.
      GG vs. AA 117 237 1.12 (0.54–2.35) 0.76 0.17 46.4 n.a.
      GA vs. AA 86 171 1.18 (0.55–2.52) 0.67 0.22 34.9 n.a.
IL23R rs10889677 2 Caucasians, Japanese C vs. A 400 604 1.15 (0.46–2.86) 0.76 0.0018 89.7 n.a.
      CC vs. CA + AA 200 302 1.40 (0.46–4.21) 0.55 0.040 77.1 n.a.
      CC + CA vs. AA 200 302 0.93 (0.37–2.32) 0.87 0.12 58.5 n.a.
      CC vs. AA 132 163 1.20 (0.31–4.66) 0.80 0.070 70.1 n.a.
      CA vs. AA 129 238 0.72 (0.44–1.15) 0.17 0.44 0.0 n.a.
IL23R rs2201841 2 Caucasians, Japanese A vs. G 402 606 1.20 (0.55–2.63) 0.65 0.010 86.3 n.a.
      AA vs. AG + GG 201 303 1.60 (0.70–3.66) 0.26 0.10 64.0 n.a.
      AA + AG vs. GG 201 303 0.80 (0.51–1.25) 0.33 0.23 30.2 n.a.
      AA vs. GG 133 163 1.17 (0.58–2.36) 0.65 0.19 41.5 n.a.
      AG vs. GG 127 238 0.72 (0.45–1.16) 0.18 0.62 0.0 n.a.
IL23R rs7530511 2 Caucasians, Japanese C vs. T 396 580 0.68 (0.39–1.17) 0.16 0.41 0.0 n.a.
      CC vs. CT + TT 198 290 0.64 (0.35–1.18) 0.15 0.43 0.0 n.a.
      CC + CT vs. TT 198 290 0.64 (0.12–3.32) 0.60 0.90 0.0 n.a.
      CC vs. TT 168 268 0.59 (0.11–3.09) 0.53 0.93 0.0 n.a.
      CT vs. TT 33 24 0.98 (0.17–5.50) 0.98 0.80 0.0 n.a.

CI: Confidence interval; FEM: fixed effects model; GD: Grave’s Disease; GO: Graves’ Ophthalmopathy; IL: Interleukin; IL1A: Interleukin 1 Alpha; IL1B: Interleukin 1 Beta; IL1RA: Interleukin 1 Receptor Antagonist; IL12B: Interleukin 12 Beta; IL23R: Interleukin 23 Receptor; No.: number; OR: Odds ratio; REM: random effects model.

aIf the P value for Q-statistic was <0.10 or the I2 value ≥ 50%, a random-effects model was used, otherwise a fixed-effects model was adopted.

bA2 = 2 repeats of a 86-bp segment; non-A2 = other number of repeats of a 86-bp segment.